Format

Send to

Choose Destination
Biochem Soc Trans. 2017 Feb 8;45(1):155-162. doi: 10.1042/BST20160265.

The LRRK2-macroautophagy axis and its relevance to Parkinson's disease.

Author information

1
School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6AP, U.K. c.manzoni@reading.ac.uk.
2
Department of Molecular Neuroscience, University College London, Queen Square House, London WC1N 3BG, U.K.

Abstract

A wide variety of different functions and an impressive array of interactors have been associated with leucine-rich repeat kinase 2 (LRRK2) over the years. Here, I discuss the hypothesis that LRRK2 may be capable of interacting with different proteins at different times and places, therefore, controlling a plethora of diverse functions based on the different complexes formed. Among these, I will then focus on macroautophagy in the general context of the endolysosomal system. First, the relevance of autophagy in Parkinson's disease will be evaluated giving a brief overview of all the relevant Parkinson's disease genes; then, the association of LRRK2 with macroautophagy and the endolysosomal pathway will be analyzed based on the supporting literature.

KEYWORDS:

Parkinson's disease; autophagy; leucine-rich repeat kinase; neurodegeneration

PMID:
28202669
PMCID:
PMC5310720
DOI:
10.1042/BST20160265
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center