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J Epidemiol. 2017 Mar;27(3S):S49-S57. doi: 10.1016/j.je.2016.12.010. Epub 2017 Feb 13.

Characteristics and prognosis of Japanese male and female lung cancer patients: The BioBank Japan Project.

Author information

1
Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
2
Laboratory of Genome Technology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
3
Department of Public Policy, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
4
Department of Health Sciences, University of Yamanashi, Yamanashi, Japan.
5
Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
6
Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan.
7
Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
8
Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
9
RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
10
Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, USA.
11
Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: tamaa@med.hokudai.ac.jp.
12
Tokushukai Hospitals, Japan.
13
Nippon Medical School, Japan.
14
Juntendo University, Japan.
15
Nihon University, Japan.
16
Iwate Medical University, Japan.
17
Tokyo Metropolitan Institute of Gerontology, Japan.
18
The Cancer Institute Hospital of JFCR, Japan.
19
Aso Iizuka Hospital, Japan.
20
Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
21
Shiga University of Medical Science, Japan.
22
National Hospital Organization, Osaka National Hospital, Japan.
23
Fukujuji Hospital, Japan.

Abstract

BACKGROUND:

In Japanese males and females, lung cancer is currently the second and fourth most common type of cancer, and the first and second leading cause of cancer-related deaths, respectively.

METHODS:

Of all Japanese male and female lung cancer patients aged ≥20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 764 males and 415 females were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry. Furthermore, we examined the effect of these characteristics on all-cause mortality.

RESULTS:

In the lung cancer patients registered within 90 days, the frequencies of occult or stage 0, stage I, II, III and IV were 0.4%, 55.8%, 10.8%, 22.0% and 11.0% for males and 0.3%, 62.4%, 9.9%, 17.1% and 10.2% for females, respectively. The proportions of histological types in males and females were 56.3% and 82.4% for adenocarcinoma, 26.9% and 8.2% for squamous cell carcinoma, 4.5% and 1.5% for large cell carcinoma, 7.7% and 4.1% for small cell carcinoma and 4.6% and 3.8% for others, respectively. Among 1120 participants who registered within 90 days, 572 participants died during 5811 person-years of follow-up. Low body mass index, ever smoker, more advanced stage, squamous cell or small cell carcinoma and high serum carcinoembryonic antigen level at study entry were crudely associated with an increased risk of all-cause mortality after adjustment for age.

CONCLUSIONS:

This study showed the association of several lifestyle and clinical characteristics with all-cause mortality in lung cancer patients.

KEYWORDS:

Histological type; Lung cancer; Mortality; Smoking; Stage

PMID:
28202209
PMCID:
PMC5350589
DOI:
10.1016/j.je.2016.12.010
[Indexed for MEDLINE]
Free PMC Article

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