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BMC Nephrol. 2017 Feb 15;18(1):64. doi: 10.1186/s12882-017-0484-y.

Prevalence and risk factors for Human T-Lymphotropic Virus Type 1 (HTLV-1) among maintenance hemodialysis patients.

Author information

1
Division of Nephrology, Hospital Geral Roberto Santos, Salvador, Brazil. rilma_santos@yahoo.com.br.
2
Postgraduate Program in Health Sciences, Federal University of Bahia, Salvador, Brazil. rilma_santos@yahoo.com.br.
3
Department of Biochemistry, APAE, Salvador, Brazil.
4
Unit of Clinical Epidemiology and Evidence Based Medicine of the Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Brazil.
5
Diretoria Médica da Clínica Nephron-Itapuã, Salvador, Brazil.
6
Centro de Pesquisas Gonçalo Moniz (Fiocruz-Ba), Salvador, Brazil.
7
Department of Internal Medicine and Diagnostic Support, Medical School of Bahia, Federal University of Bahia, Salvador, Brazil.
8
Postgraduate Program in Health Sciences, Federal University of Bahia, Salvador, Brazil.

Abstract

BACKGROUND:

Infection with the human T-cell lymphotropic virus type 1 (HTLV-1), although asymptomatic in most cases, can lead to potentially grave consequences, such as adult T-cell leukemia-lymphoma and HTLV-1-associated myelopathy / tropical spastic paraparesis. Its prevalence varies widely across different populations and geographic regions. A population-based study in the city of Salvador, located in the Northeast region of Brazil, showed an overall prevalence of HTLV-1 seropositivity of 1.7%. Blood borne virus infections are recognized as important hazards for patients and staff in maintenance hemodialysis (MHD) units but most studies focus on hepatitis B, hepatitis C and human immunodeficiency viruses. There are scarce data about HTLV-1 infection in the MHD population. We aimed to determine the prevalence and risk factors for HTLV-1 infection among MHD patients in the city of Salvador-Bahia, Brazil.

METHODS:

We conducted a multi-center, cross-sectional study nested in a prospective cohort of MHD patients enrolled from four outpatient clinics. HTLV-1 screening was performed with ELISA and positive cases were confirmed by Western Blot. Factors associated with HTLV-1 seropositivity were identified by multivariable logistic regression.

RESULTS:

605 patients were included in the study. The overall prevalence of HTLV-1 infection was 2.48% (15/605), which was similar to that of hepatitis B [1.98% (12/605)] and C [3.14% (19/605)] viruses in our sample. HTLV-1 seropositivity was positively associated with age [prevalence odds ratio (POR) 1.04; 95% confidence interval (CI) 1.01-1.08], unmarried status (POR 3.65; 95% CI 1.13-11.65), and history of blood transfusion (POR 3.35; 95% CI 1.01-11.13).

CONCLUSIONS:

The overall prevalence of HTLV-1 infection in a sample of MHD patients was similar to that of other viral infections, such as hepatitis B and C. Our data revealed that MHD patients who are older, unmarried or who have received blood transfusions are at higher risk for HTLV-1 infection.

KEYWORDS:

Blood Transfusion; Chronic Kidney 47 Disease; Hemodialysis; Hepatitis B; Hepatitis C; Human T-Lymphotropic Virus Type 1

PMID:
28202003
PMCID:
PMC5312583
DOI:
10.1186/s12882-017-0484-y
[Indexed for MEDLINE]
Free PMC Article

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