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Curr Pharm Des. 2017;23(18):2623-2643. doi: 10.2174/1381612823666170214120708.

Cell-based Tolerogenic Therapy, Experience from Animal Models of Multiple Sclerosis, Type 1 Diabetes and Rheumatoid Arthritis.

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Department of Immunology, Institute for Biological Research "Sinisa Stankovis", University of Belgrade, Belgrade, Serbia.
Immunology Division, Germans Trias i Pujol University Hospital, Department of Cellular Biology, Physiology, and Immunology, Universitat Autònoma Barcelona, Campus Can Ruti, 08916 Barcelona, Spain.
SOTIO a.s., Prague, Czech Republic.
Department of Immunology and Gnotobiology, Institute of Microbiology of the CAS,v.v.i., Prague, Czech Republic.
Department for Immunology and Immunoparasitology, Institute for the Application of Nuclear Energy - INEP, University of Belgrade, Belgrade, Serbia.
Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, NE2 4HH, United Kingdom.
Institute for Biological Research "Sinisa Stankovic", Department of Immunology, Despota Stefana 142, 11000 Belgrade, Serbia.


Cell-based tolerogenic therapy is a promising approach for the treatment of autoimmune diseases and transplant rejection. Regulatory T cells and tolerogenic dendritic cells have been particularly explored in the treatment of various autoimmune disorders in experimental models of disease. Although some of these cells have already been tested in a limited number of clinical trials, there is still a need for preclinical research on tolerogenic cells in animal models of autoimmunity. This review will focus on the relevance of data obtained from studies in experimental animal models for the use of tolerogenic cell-based therapy in humans. Also, perspectives for further improvement of tolerogenic cell preparation towards enhanced suppressive activity and stability of the cells will be discussed.


Cell-based tolerogenic therapy; multiple sclerosis; regulatory T cells; rheumatoid arthritis; tolerogenic dendritic cells; type 1 diabetes

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