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Bioinformatics. 2017 Jul 1;33(13):2056-2058. doi: 10.1093/bioinformatics/btx075.

LASER server: ancestry tracing with genotypes or sequence reads.

Author information

1
Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
2
Computational and Systems Biology, Genome Institute of Singapore, Singapore 138672, Singapore.
3
Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck 6020, Austria.

Abstract

Summary:

To enable direct comparison of ancestry background in different studies, we developed LASER to estimate individual ancestry by placing either sezquenced or genotyped samples in a common ancestry space, regardless of the sequencing strategy or genotyping array used to characterize each sample. Here we describe the LASER server to facilitate application of the method to a wide range of genetic studies. The server provides genetic ancestry estimation for different geographic regions and user-friendly interactive visualization of the results.

Availability and Implementation:

The LASER server is freely accessible at http://laser.sph.umich.edu/.

Contact:

dtaliun@umich.edu or wangcl@gis.a-star.edu.sg.

Supplementary information:

Supplementary data are available at Bioinformatics online.

PMID:
28200055
PMCID:
PMC5870850
DOI:
10.1093/bioinformatics/btx075
[Indexed for MEDLINE]
Free PMC Article

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