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BMC Genomics. 2017 Jan 25;18(Suppl 1):950. doi: 10.1186/s12864-016-3256-3.

Exploring the key genes and signaling transduction pathways related to the survival time of glioblastoma multiforme patients by a novel survival analysis model.

Xia Y1, Yang C2,3, Hu N4, Yang Z4, He X5, Li T6, Zhang L7,8.

Author information

1
College of Computer and Information Science, Southwest University, Chongqing, 400715, People's Republic of China.
2
Systems Biology, the University of Texas MD Anderson Cancer Center, Houston, USA.
3
Breast Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, USA.
4
Cancer Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, 400042, People's Republic of China.
5
Chongqing Zhongdi Medical Information Technology Co., Ltd, Chongqing, 401320, People's Republic of China.
6
College of Mathematics and Statistics, Southwest University, Chongqing, 400715, People's Republic of China. tinalee@swu.edu.cn.
7
College of Computer and Information Science, Southwest University, Chongqing, 400715, People's Republic of China. zhanglcq@swu.edu.cn.
8
College of Mathematics and Statistics, Southwest University, Chongqing, 400715, People's Republic of China. zhanglcq@swu.edu.cn.

Abstract

BACKGROUND:

This study is to explore the key genes and signaling transduction pathways related to the survival time of glioblastoma multiforme (GBM) patients.

RESULTS:

Our results not only showed that mutually explored GBM survival time related genes and signaling transduction pathways are closely related to the GBM, but also demonstrated that our innovated constrained optimization algorithm (CoxSisLasso strategy) are better than the classical methods (CoxLasso and CoxSis strategy).

CONCLUSION:

We analyzed why the CoxSisLasso strategy can outperform the existing classical methods and discuss how to extend this research in the distant future.

KEYWORDS:

Cox proportional hazards model (Cox); Glioblastoma multiforme (GBM); Least absolute shrinkage and selection operator (Lasso); Signaling transduction pathway; Sure independence screening (SIS)

PMID:
28198665
PMCID:
PMC5310279
DOI:
10.1186/s12864-016-3256-3
[Indexed for MEDLINE]
Free PMC Article

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