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Magn Reson Med. 2018 Jan;79(1):394-400. doi: 10.1002/mrm.26643. Epub 2017 Feb 15.

A constrained slice-dependent background suppression scheme for simultaneous multislice pseudo-continuous arterial spin labeling.

Author information

1
Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Soutern California, Los Angeles, California, USA.
2
MR Clinical Science, Philips Healthcare, Gainesville, Florida, USA.
3
Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA.

Abstract

PURPOSE:

To present a constrained slice-dependent (CSD) background-suppression (BS) scheme in 2D arterial spin labeling (ASL) using simultaneous multislice acquisition with blipped-CAIPIRINHA (controlled aliasing in parallel imaging results in higher acceleration).

METHODS:

Background suppression for 2D acquisition is challenging because of the multiple nulling points required for sequential slice readout. Constrained slice-dependent BS exploits the simultaneous multislice technique to reduce the readout duration, and uses slice-dependent premodulation pulses to achieve BS across slice groups. The proposed scheme was evaluated by in vivo brain experiments at 3 Tesla with multiband acceleration factors up to four. The utility of CSD BS was demonstrated through comparison against standard 2D acquisitions as well as 3D-BS pseudo-continuous ASL (pCASL).

RESULTS:

An average of 95% background signal reduction was achieved with CSD BS. As a result, the temporal signal-to-noise ratio (SNR) increased 48.2/39.9/36.9/36.0% and spatial SNR increased 132.5/80.0/63.5/54.2 in CSD-BS MB-1/2/3/4 scans, respectively. Whole-brain coverage was achievable with CSD-BS pCASL with MB-4, which yielded comparable spatial SNR as 3D BS pCASL.

CONCLUSIONS:

The proposed CSD-BS scheme for 2D-SMS pCASL offers a promising approach for effective suppression of background signals across a wide range of T1 to achieve whole-brain perfusion imaging. Magn Reson Med 79:394-400, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

KEYWORDS:

arterial spin labeling (ASL); background suppression (BS); controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA); simultaneous multislice (SMS)

PMID:
28198576
PMCID:
PMC5557712
DOI:
10.1002/mrm.26643
[Indexed for MEDLINE]
Free PMC Article

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