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Angew Chem Int Ed Engl. 2017 Mar 13;56(12):3140-3141. doi: 10.1002/anie.201612543. Epub 2017 Feb 15.

The First Biocatalytic Carbon-Silicon Bond Formation.

Author information

1
Department of Biochemical and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44221, Dortmund, Germany.

Abstract

Linking two worlds: As a further expansion of the biocatalytic repertoire, carbene insertion into Si-H bonds catalyzed by the heme protein cytochrome c was recently reported. This new biocatalyst holds great promise because it enables the highly selective incorporation of silicon into molecules without prior protection of existing functional groups.

KEYWORDS:

biocatalysis; biotransformations; cytochrome P450; enzymes; protein engineering

PMID:
28198074
DOI:
10.1002/anie.201612543

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