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Arch Gynecol Obstet. 2017 Apr;295(4):1025-1032. doi: 10.1007/s00404-017-4290-3. Epub 2017 Feb 14.

The effect of slow release insemination on pregnancy rates: report of two randomized controlled pilot studies and meta-analysis.

Author information

1
Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
2
Lin Medical Center, Haifa, Israel.
3
Department of Obstetrics and Gynecology, Interdisciplinary Center for Reproductive Medicine (UniKiD), University of Düesseldorf, Düesseldorf, Germany.
4
Aqueduct Medical Ltd., Nazareth, Israel.
5
Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. johannes.ott@meduniwien.ac.at.

Abstract

PURPOSE:

A modified application technique of intrauterine insemination (IUI) is slow release insemination (SRI), first described by Muharib et al. (Hum Reprod 7(2):227-229, 1992), who postulated higher pregnancy rates with a slow release of spermatozoa for 3 h.

METHODS:

To investigate this approach, two randomized controlled, cross-over pilot studies were performed from 2004 to 2006 in Israel and Germany to compare SRI with the standard bolus IUI. We aimed to present the results and perform a meta-analysis on available data for SRI. Univariate comparisons of pregnancy rates were performed using one-tailed z tests for method superiority. For meta-analysis, a fixed-effect Mantel-Haentzel weighted average of relative risk was performed.

RESULTS:

Fifty treatment cycles (IUI: n = 25, SRI: n = 25) were performed in Germany, achieving four pregnancies (IUI: 4%, SRI: 12%, p > 0.05). Thirty-nine treatment cycles (IUI: n = 19, SRI: n = 20) were performed in Israel achieving six pregnancies (IUI: 10.5%, SRI: 20%; p > 0.05). Meta-analysis of all eligible studies for SRI (n = 3) revealed a combined relative risk for pregnancy after SRI of 2.64 (95% CI 1.04-6.74), p = 0.02).

CONCLUSIONS:

In conclusion, these results lend support to the hypothesis that the pregnancy rate might be improved by SRI compared to the standard bolus technique.

KEYWORDS:

Infertility; Intrauterine insemination; Outcome; Pregnancy rate; Slow release insemination

PMID:
28197716
PMCID:
PMC5350232
DOI:
10.1007/s00404-017-4290-3
[Indexed for MEDLINE]
Free PMC Article

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