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J Nephropharmacol. 2015 May 19;5(2):80-85. eCollection 2016.

Impacts of Hibiscus esculentus extract on glucose and lipid profile of diabetic rats.

Author information

1
Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran.
2
Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran.
3
Nickan Research Institute, Isfahan, Iran.

Abstract

Introduction:Hibiscus esculentus is capable to produce various molecules including phenolic and flavonoid compounds, phytosteroids with antioxidant property. Therefore, it has the potential to show antidiabetic activities. Objectives: This study was aimed to evaluate the impacts of Hibiscus esculentus extract on glucose and lipid profile of diabetic rats. The flavonoid, flavonol and phenolic components, as well as antioxidant activity of Hibiscus esculentus was also evaluated. Materials and Methods: In a preclinical study, 40 male Wistar rats were designated into four 10-member groups, i.e., control, diabetic control, diabetic Hibiscus esculentus, and diabetic glibenclamide. The Alloxan-induced diabetic rats received extracts orally for four weeks. Then, the serum biochemical factors were measured and compared by analysis of variance (ANOVA). Results: Serum glucose, triglyceride (TG), cholesterol, and low density lipoprotein cholesterol (LDL-C) were significantly decreased and high density lipoprotein cholesterol (HDL-C) increased in diabetic Hibiscus esculentus rats compared to diabetic control ones (P < 0.05). Conclusion: Improving the blood glucose and lipid profile in diabetic rats indicates that Hibiscus esculentus extract might be beneficial in diabetic patients.

KEYWORDS:

Diabetes mellitus; Hibiscus esculentus; Hyperglycemia; Lipid profile

PMID:
28197508
PMCID:
PMC5297571

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