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Neural Regen Res. 2016 Dec;11(12):2012-2017. doi: 10.4103/1673-5374.197146.

Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves.

Author information

1
Department of Oral & Maxillofacial Surgery, The General Hospital of the People's Liberation Army, Beijing, China; Department of Oral & Maxillofacial Surgery, Binzhou Medical University, Yantai, Shandong Province, China.
2
Metal Research Institute of Chinese Academy of Sciences, Shenyang, Liaoning Province, China.
3
Department of Oral & Maxillofacial Surgery, Peking University Third Hospital, Beijing, China.

Abstract

Magnesium (Mg) wire has been shown to be biodegradable and have anti-inflammatory properties. It can induce Schwann cells to secrete nerve growth factor and promote the regeneration of nerve axons after central nervous system injury. We hypothesized that biodegradable Mg wire may enhance compressed peripheral nerve regeneration. A rat acute sciatic nerve compression model was made, and AZ31 Mg wire (3 mm diameter; 8 mm length) bridged at both ends of the nerve. Our results demonstrate that sciatic functional index, nerve growth factor, p75 neurotrophin receptor, and tyrosine receptor kinase A mRNA expression are increased by Mg wire in Mg model. The numbers of cross section nerve fibers and regenerating axons were also increased. Sciatic nerve function was improved and the myelinated axon number was increased in injured sciatic nerve following Mg treatment. Immunofluorescence histopathology showed that there were increased vigorous axonal regeneration and myelin sheath coverage in injured sciatic nerve after Mg treatment. Our findings confirm that biodegradable Mg wire can promote the regeneration of acute compressed sciatic nerves.

KEYWORDS:

P75 neurotrophin receptor; biodegradable; magnesium wire; nerve growth factor; nerve regeneration; neural regeneration; peripheral nerve regeneration; rats; sciatic nerve; tyrosine receptor kinase A

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