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J Oncol Pract. 2017 Apr;13(4):e395-e400. doi: 10.1200/JOP.2016.018390. Epub 2017 Feb 14.

Implementing a Method for Evaluating Patient-Reported Outcomes Associated With Oral Oncolytic Therapy.

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Michigan Oncology Quality Consortium; University of Michigan Medical School; University of Michigan Health System; University of Michigan School of Public Health, Ann Arbor, MI; and Stanford Cancer Institute, Stanford, CA.



The paradigm shift in health care toward value-based reimbursement has brought emphasis to providing better quality of care to patients with chronic diseases, including patients with cancer. In accordance with providing better quality of care to patients, there has been a growing interest in evaluating quality of life through patient-reported outcomes (PROs). The revised Edmonton Symptom Assessment Scale (ESAS-r) is a tool that can be used to assess PROs and has been validated for use in patients with cancer. This initiative sought to use this standard assessment tool to acquire PROs concerning symptom burden from patients prescribed oral oncolytics.


Eight oncology practices in the state of Michigan used a modified ESAS-r to evaluate symptom burden of patients prescribed oral oncolytics before each outpatient visit. Thirteen symptoms were categorized as mild (0 to 3), moderate (4 to 6), or severe (7 to 10).


A total of 1,235 modified ESAS-r surveys were collected and analyzed; 82.5% of symptoms were categorized as mild, 11.9% of symptoms were categorized as moderate, and 5.6% of symptoms were categorized as severe.


PROs can be evaluated through the use of a standardized tool, such as the ESAS-r, in oncology patients receiving oral oncolytic therapy. Implementing such a tool in both community and academic practices is feasible and may facilitate improvements in the quality of care.

[Indexed for MEDLINE]

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