Format

Send to

Choose Destination
Antivir Ther. 2017;22(6):529-533. doi: 10.3851/IMP3137. Epub 2017 Feb 14.

Impact of tenofovir dose adjustment on both estimated glomerular filtration rate and tenofovir trough concentration.

Author information

1
Aix-Marseille University, APHM Sainte-Marguerite, Service d'Immuno-hématologie clinique, Marseille, France.
2
Aix-Marseille University, APHM La Timone, Pharmacocinétique et Toxicologie, INSERM S_911 CRO2-SMARTc, Marseille, France.
3
IHU Méditerranée Infection, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, APHM Timone, Marseille, France.
4
INSERM U912 (SESSTIM), Marseille, France.

Abstract

BACKGROUND:

Tenofovir disoproxil fumarate (TDF)-based regimen is a treatment option for HIV-infected patients. TDF dose adjustment is recommended in patients with impaired renal function. We assessed the impact of TDF dose adjustment on renal function and tenofovir trough concentration.

METHODS:

Fourteen HIV patients for whom TDF dose was adjusted (1 tablet/48 h) because of estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2, and/or due to a tenofovir trough concentration >90 ng/ml between 2006 and 2013 were selected. The eGFR was measured at baseline and 3, 6 and 12 months after TDF dose adjustment.

RESULTS:

A 50% TDF dose reduction resulted in a significant increase of the eGFR 3 months after dose adjustment (61.1 versus 72.8 ml/min/1.73 m2; P=0.003). Concomitantly, tenofovir trough concentration decreased from 175 to 66 ng/ml (P=0.009). Antiviral efficacy was maintained in all patients.

CONCLUSIONS:

TDF dose adjustment combined with therapeutic drug monitoring may be useful especially in patients at risk of kidney dysfunction.

PMID:
28195560
DOI:
10.3851/IMP3137
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center