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Neuropsychopharmacology. 2017 Oct;42(11):2152-2162. doi: 10.1038/npp.2017.35. Epub 2017 Feb 14.

Altered Insula Connectivity under MDMA.

Author information

1
Department of Psychiatry, McGill University Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
2
Division of Brain Sciences, Faculty of Medicine, Centre for Neuropsychopharmacology, Imperial College London, London, UK.
3
The Beckley Foundation, Oxford, UK.

Abstract

Recent work with noninvasive human brain imaging has started to investigate the effects of 3,4-methylenedioxymethamphetamine (MDMA) on large-scale patterns of brain activity. MDMA, a potent monoamine-releaser with particularly pronounced serotonin- releasing properties, has unique subjective effects that include: marked positive mood, pleasant/unusual bodily sensations and pro-social, empathic feelings. However, the neurobiological basis for these effects is not properly understood, and the present analysis sought to address this knowledge gap. To do this, we administered MDMA-HCl (100 mg p.o.) and, separately, placebo (ascorbic acid) in a randomized, double-blind, repeated-measures design with twenty-five healthy volunteers undergoing fMRI scanning. We then employed a measure of global resting-state functional brain connectivity and follow-up seed-to-voxel analysis to the fMRI data we acquired. Results revealed decreased right insula/salience network functional connectivity under MDMA. Furthermore, these decreases in right insula/salience network connectivity correlated with baseline trait anxiety and acute experiences of altered bodily sensations under MDMA. The present findings highlight insular disintegration (ie, compromised salience network membership) as a neurobiological signature of the MDMA experience, and relate this brain effect to trait anxiety and acutely altered bodily sensations-both of which are known to be associated with insular functioning.

PMID:
28195139
PMCID:
PMC5603811
DOI:
10.1038/npp.2017.35
[Indexed for MEDLINE]
Free PMC Article

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