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Nat Commun. 2017 Feb 14;8:14415. doi: 10.1038/ncomms14415.

Low-frequency theta oscillations in the human hippocampus during real-world and virtual navigation.

Author information

1
Douglas Institute, Department of Psychiatry, McGill University, 6875 boulevard LaSalle, Verdun, Quebec, Canada H4H 1R3.
2
Neuroscience Graduate Group, University of California, Davis, 1 Shields Avenue, Davis, California 95616, USA.
3
Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4.
4
Center for Neuroscience, University of California, Davis, 1 Shields Avenue, Davis, California 95618, USA.
5
Department of Psychology, University of California, Davis, 1 Shields Avenue, Davis, California 95618, USA.

Abstract

Low-Frequency Oscillations (LFO) in the range of 7-9 Hz, or theta rhythm, has been recorded in rodents ambulating in the real world. However, intra-hippocampus EEG recordings during virtual navigation in humans have consistently reported LFO that appear to predominate around 3-4 Hz. Here we report clear evidence of 7-9 Hz rhythmicity in raw intra-hippocampus EEG traces during real as well as virtual movement. Oscillations typically occur at a lower frequency in virtual than real world navigation. This study highlights the possibility that human and rodent hippocampal EEG activity are not as different as previously reported and this difference may arise, in part, due to the lack of actual movement in previous human navigation studies, which were virtual.

PMID:
28195129
PMCID:
PMC5316881
DOI:
10.1038/ncomms14415
[Indexed for MEDLINE]
Free PMC Article

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