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Ann Biomed Eng. 2017 Jun;45(6):1487-1495. doi: 10.1007/s10439-017-1810-z. Epub 2017 Feb 13.

A Novel Apparatus for the Multifaceted Evaluation of Arterial Function Through Transmural Pressure Manipulation.

Author information

1
Biomechanics Laboratory, Department of Mechanical Engineering, Nagoya Institute of Technology, Nagoya, 466-8555, Japan. tyaguchi@mail.dendai.ac.jp.
2
Division of Electronic and Mechanical Engineering, Department of Science and Engineering, School of Science and Engineering, Tokyo Denki University, Hikigun, 350-0394, Japan. tyaguchi@mail.dendai.ac.jp.
3
Biomechanics Laboratory, Department of Mechanical Engineering, Nagoya Institute of Technology, Nagoya, 466-8555, Japan.
4
Department of Intelligent Systems Engineering, College of Engineering, Ibaraki University, Hitachi, 316-8511, Japan.
5
UNEX Corporation, Nagoya, 460-0008, Japan.
6
Biomechanics Laboratory, Department of Mechanical Engineering, Nagoya Institute of Technology, Nagoya, 466-8555, Japan. takeo@nagoya-u.jp.
7
Biomechanics Laboratory, Department of Mechanical Science and Engineering, Graduate School of Engineering, Nagoya University, Nagoya, 464-8603, Japan. takeo@nagoya-u.jp.

Abstract

A novel apparatus for the multifaceted evaluation of artery function was developed. It measures endothelial and smooth muscle functions and the pressure-strain elastic modulus (E p). A rigid airtight chamber with an ultrasound probe was attached to the upper arm to manipulate the transmural pressure of the brachial artery. Endothelial function was measured via a standard flow-mediated dilation (FMD) protocol. Smooth muscle function was evaluated via a myogenic contraction of the artery following the application of negative pressure to the chamber and was named pressure-mediated contraction (PMC). E p was obtained by measuring the instantaneous increase in the artery diameter following the negative pressure application. The PMC and FMD values had a significant negative correlation with age, indicating that the age-related decrease in FMD is caused by the decay of endothelial and smooth muscle function. A consideration of PMC may help improve the accuracy of artery function measurement. E p in subjects aged >40 years was found to be significantly higher in the supra-physiological pressure range than in the physiological one (p = 0.02); this did not occur in younger subjects. Artery stiffening may begin in the supra-physiological range, and this stiffness may also be used for the diagnosis of atherosclerosis.

KEYWORDS:

Atherosclerosis; Bayliss effect; Endothelial cell; Flow-mediated dilation; Smooth muscle cell

PMID:
28194660
DOI:
10.1007/s10439-017-1810-z
[Indexed for MEDLINE]

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