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Front Physiol. 2017 Jan 30;8:35. doi: 10.3389/fphys.2017.00035. eCollection 2017.

Dynamic and Static Exercises Differentially Affect Plasma Cytokine Content in Elite Endurance- and Strength-Trained Athletes and Untrained Volunteers.

Author information

1
Department of Sports Tourism Sports Physiology and Medicine, National Research Tomsk State UniversityTomsk, Russia; Department of Sports Disciplines, National Research Tomsk Polytechnic UniversityTomsk, Russia.
2
Department of Sports Tourism Sports Physiology and Medicine, National Research Tomsk State University Tomsk, Russia.
3
Department of Sports Tourism Sports Physiology and Medicine, National Research Tomsk State UniversityTomsk, Russia; Laboratory of Physical Chemistry of Biomembranes, Faculty of Biology, M. V. Lomonosov Moscow State UniversityMoscow, Russia.

Abstract

Extensive exercise increases the plasma content of IL-6, IL-8, IL-15, leukemia inhibitory factor (LIF), and several other cytokines via their augmented transcription in skeletal muscle cells. However, the relative impact of aerobic and resistant training interventions on cytokine production remains poorly defined. In this study, we compared effects of dynamic and static load on cytokine plasma content in elite strength- and endurance-trained athletes vs. healthy untrained volunteers. The plasma cytokine content was measured before, immediately after, and 30 min post-exercise using enzyme-linked immunosorbent assay. Pedaling on a bicycle ergometer increased IL-6 and IL-8 content in the plasma of trained athletes by about 4- and 2-fold, respectively. In contrast to dynamic load, weightlifting had negligible impact on these parameters in strength exercise-trained athletes. Unlike IL-6 and IL-8, dynamic exercise had no impact on IL-15 and LIF, whereas static load increases the content of these cytokines by ~50%. Two-fold increment of IL-8 content seen in athletes subjected to dynamic exercise was absent in untrained individuals, whereas the ~50% increase in IL-15 triggered by static load in the plasma of weightlifting athletes was not registered in the control group. Thus, our results show the distinct impact of static and dynamic exercises on cytokine content in the plasma of trained athletes. They also demonstrate that both types of exercises differentially affect cytokine content in plasma of athletes and untrained persons.

KEYWORDS:

dynamic exercise; interleukins; leukemia inhibitory factor; static exercise; trained athletes and untrained volunteers

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