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ACS Chem Biol. 2017 Apr 21;12(4):886-891. doi: 10.1021/acschembio.7b00010. Epub 2017 Feb 21.

Mechanistic Debris Generated by Twister Ribozymes.

Author information

1
Department of Molecular, Cellular and Developmental Biology, ‡Department of Molecular Biophysics and Biochemistry, §Howard Hughes Medical Institute, Yale University , New Haven, Connecticut 06520, United States.

Abstract

Twister RNAs represent a recently discovered class of natural ribozymes that promote rapid cleaving of RNA backbones. Although an abundance of theoretical, biochemical, and structural data exist for several members of the twister class, disagreements about the architecture and mechanism of its active site have emerged. Historically, such storms regarding mechanistic details typically occur soon after each new self-cleaving ribozyme class is reported, but paths forward exist to quickly reach calmer conditions.

PMID:
28191925
PMCID:
PMC5778351
DOI:
10.1021/acschembio.7b00010
[Indexed for MEDLINE]
Free PMC Article

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