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Cureus. 2017 Jan 11;9(1):e972. doi: 10.7759/cureus.972.

When Nothing Else Works: Fresh Frozen Plasma in the Treatment of Progressive, Refractory Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema.

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Internal Medicine, University of Central Florida College of Medicine.
Pulmonary/Critical Care, Osceola Regional Medical Center.


Angioedema is a severe form of an allergic reaction characterized by the localized edematous swelling of the dermis and subcutaneous tissues. Angiotensin-converting enzyme inhibitor-induced angioedema (ACEI-IA) is an allergic reaction that can be severe in some cases requiring advanced management measures. Fresh frozen plasma has been used off-labeled in some case reports to improve and to prevent worsening of the angioedema in a few cases of ACEI-IA. We are reporting this case to increase the awareness of physicians and to widen their therapeutic options when encountering this clinically significant condition.


angioedema; angiotensin-converting enzyme inhibitor; fresh frozen plasma

Conflict of interest statement

The authors have declared that no competing interests exist.

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