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J Autoimmun. 2017 May;79:84-90. doi: 10.1016/j.jaut.2017.01.005. Epub 2017 Feb 9.

Risk of autoimmune diseases and human papilloma virus (HPV) vaccines: Six years of case-referent surveillance.

Collaborators (221)

Abbas F21, Abdelmoumni A22, Hilliquin P22, Requeda E22, Adoue D23, Brassat D23, Agard C24, Masseau A24, Aladjidi N25, Clet J25, Fernandes H25, Lemasson G25, Perel Y25, Raymond I25, Richer O25, Vital A25, Allain-Launay E26, Bru M26, Nicolino M26, Thomas C26, Altman JJ27, Amsallem D28, Aras N29, Boukari L29, Dubrel M29, Fain O29, Letellier E29, Lucidarme N29, Mekinian A29, Morin AS29, Stirnemann J29, Atlan C30, Audry D31, Augustin J32, Bakir R33, Bartolucci P34, Chevalier X34, Godeau B34, Guillaud C34, Khellaf M34, Limal N34, Lousteau V34, Mahevas M34, Méliksetyan G34, Michel M34, Roumier M34, Bayart S35, Bonnet F35, Decaux O35, Bekherraz A36, Brihaye B36, Dachez R36, Daugas E36, Hayem G36, Meyer O36, Papo T36, Pasqualoni E36, Sacre K36, Travert F36, Bellon H37, Beltrand J38, Lefrere F38, Simon A38, Benhamou PY39, Benveniste O40, Bolgert F40, Costedoat-Chalumeau N40, De Paz R40, Demeret S40, Fautrel B40, Jacqueminet S40, Louapre C40, Maillart E40, Morel N40, Papeix C40, Rigabert J40, Bensaid P41, Berger C42, Berquin P43, Le Moing AG43, Berroir S44, Besson G45, Boutte C45, Casez O45, Bonnotte B46, Audia S46, Bossu-Estour C47, Bourgarit A48, Dupuy A48, Keshmandt H48, Bourre B49, Brac A50, Perrin A50, Pondarré C50, Villar-Fimbel S50, Bruckert I51, Cosson A51, Magy-Bertrand N51, Tisserand G51, Camu W52, Carlander B52, Morales RJ52, Cances C53, Pasquet M53, Castilla Lievre MA54, Chabroux S55, Charif M56, Chatelus E57, Sibilia J57, Chevrant-Breton J58, Clavel S59, Bille-Turc F60, Cohen J60, Courcoux MF61, Leverger G61, Machet L61, Cuisset JM62, Cony-Makhoul P63, Darsy P63, Favre S63, Giraud P63, Leitenschenck L63, Monteiro I63, Morati C63, DeSeze J64, Dinulescu M65, Dhaoui T66, Dommange-Romero F67, Drevard E68, Dupuis C69, Dumuis ML70, Durand JM71, Farad S72, Lecomte P72, Pierre P72, Fouyssac F73, Gaudin P74, Gautier A75, Gellen-Dautremer J76, Jarrin I76, Richette P76, Georget E77, Gras P78, Moreau T78, Giraud E79, Hacini M79, Mayer A79, Guillaumat C80, Guillaume S81, Guitton C81, Kone-Paut I81, Marsaud C81, Rossi L81, Guyot MH82, Hassler P83, Heimfert C84, Heinzlef O85, Hillion B86, Hocquelet C87, Husson H88, Ichai P89, Jeziorski E90, Deslandre CJ91, Le Guern V91, Kamenov K92, Kerlan V93, Lemoine P93, Misery L93, Pan-Petesch B93, Krivitzky A94, Labauge P95, Rodier M95, Lacade C96, Razafimahefa B96, Lachgar K97, Larmarau MP98, Leblanc T99, Lebrun-Frenay C100, Lefèbvre P101, Lejoyeux P102, Leske C103, Ly K104, Magy L104, Mansuy S105, Marechaud R106, Martin Negrier ML107, Sole G107, Maupetit J108, Mazingue F109, Mochon S110, Moktar B111, Morcamp D112, Morlet-Barla N113, Nicolas G114, Pautot V114, Pellier I114, Verret JL114, Outteryck O115, Vermersch P115, Pallot-Prades B116, Paquet JM117, Puechal X117, Sortais A117, Pelletier J118, Rico A118, Pez D119, Stankoff B119, Quittet P120, Rémy C121, Roba E122, Rosario H123, Roudaut N124, Sonnet E124, Ruel M125, Sebban S126, Schaepelynck P127, Simonin MJ128, Vial C129, Viallard JF130, Ladedan I131, Zenone T131.

Author information

1
LASER Analytica, 10 Place de Catalogne, 75014 Paris, France; Conservatoire National des Arts et Métiers, 292 Rue Saint-Martin, 75003 Paris, France. Electronic address: Lamiae.Grimaldi@la-ser.com.
2
LASER Analytica, 10 Place de Catalogne, 75014 Paris, France; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1,020 Pine ave. West, Montréal, Québec, H3A 1A2, Canada. Electronic address: Michel.Rossignol@mcgill.ca.
3
Service de Rhumatologie Pédiatrie, Centre Hospitalier Universitaire (CHU) Kremlin Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin-Bicêtre, 3 Avenue Victoria, 75004 Paris, France; Centre de Référence des Maladies Auto-Inflammatoires (CeRéMAI), CHU de Bicêtre, 78 rue du Général Leclerc, 94270 Le Kremlin Bicêtre, France.
4
Département de Médecine Interne et Endocrinologie, Hôpital Universitaire Avicenne, Université de Paris, 125 Rue de Stalingrad, 93000 Bobigny, France.
5
Département de Neurologie, CHU de Nice, 4 Avenue Reine Victoria, 06003 Nice, France.
6
Service de Rhumatologie Pédiatrique, Centre de compétence des Arthrites Juvéniles Idiopathiques et des Maladies auto-inflammatoires, Hôpital des enfants, Place Amélie Raba Léon, 33000 Bordeaux, France.
7
Département de Neurologie, CHU de Toulouse, Place du Docteur Baylac, TSA 40031 - 31059, Toulouse, France.
8
Département de Neurologie, AP-HP, Pitié-Salpêtrière Hospital, 47-83 Boulevard de l'Hôpital, 75013 Paris, France.
9
Endocrinologie, Diabétologie, Nutrition Pédiatriques, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, 2 Avenue Doyen Jean Lépine, 69500 Bron, France.
10
Service d'Endocrinologie-Diabétologie - maladies de la nutrition, CHU Grenoble Alpes, Boulevard de la Chantourne, 38700 La Tronche, France.
11
Service de Médecine Interne, CHU de Caen, Avenue de la Côte de Nacre, 14003 Caen, France.
12
Service de Médecine Interne, Hôpital Cochin, AH-HP, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
13
Service d'Hémato-Immuno-Oncologie Pédiatrie, Hôpital Armand-Trousseau, AP-HP, 26 Avenue du Dr Arnold Netter, 75012 Paris, France.
14
Service de Médecine Interne et Maladies Infectieuses, CHU de Bordeaux, 1, rue Jean Burguet, 33000 Bordeaux, France.
15
Centre de référence des cytopénies auto-immunes de l'adulte, Service de Médecine Interne, CHU Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France.
16
Département de Médecine Interne, Hôpital Bichat, Université Paris Diderot, AP-HP, 46 Rue Henri Huchard, 75018 Paris, France; INSERM U1149, 16 rue Henri Huchard, 75890 Paris, France; Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and REmodelling in Renal and Respiratory Diseases), Université Paris Diderot, PRES Sorbonne Paris Cité, 5 Rue Thomas Mann, 75013, France.
17
Université de Lille, CHU Lille, LIRIC - INSERM U995, FHU Imminent, Hôpital Claude Huriez, Rue Michel Polonovski, 59037 Lille, France.
18
Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), 55 Avenue de Paris, 78000 Versailles, France; Inserm U1016, Institut Cochin, Department of Immunology, 22 Rue Mechain, 75014 Paris, France; UF de dermatologie-immunologie clinique, Hôpital Ambroise Paré, AP-HP, 9 Avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France.
19
Inserm UMR 1153, Équipe de recherche en épidémiologie obstétricale, périnatale et pédiatrique (EPOPé), Centre de recherche épidémiologie et statistique Sorbonne Paris Cité, DHU risques et grossesse, Université Pierre et Marie Curie, 1 place du Parvis Notre-Dame, 75004 Paris, France.
20
LASER Europe Ltd, London, 66 Chiltern St, London W1U 4JT, United Kingdom; Department of Epidemiology, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK.
21
Hôpital Louis Pasteur, Cherbourg-Octeville, France.
22
CH Sud Francilien, Corbeil Essonnes, France.
23
Hôpital Purpan, Toulouse, France.
24
CHU de Nantes, Nantes, France.
25
Hôpital Pellegrin, Bordeaux, France.
26
Hôpital Mère-Enfant, Nantes, France.
27
Hôpital Européen Georges Pompidou, Paris, France.
28
Hôpital St Jacques, Besançon, France.
29
CHU Jean Verdier, Bondy, France.
30
Hôpital Nord, Marseille, France.
31
Point Médical, Dijon, France.
32
Clinique du Cèdre, Bois Guillaume, France.
33
CHI Robert Ballanger, Villepinte, France.
34
CHU Henri Mondor, Créteil, France.
35
Hôpital Sud, Rennes, France.
36
Hôpital Bichat, Paris, France.
37
Private Practice, Marseille, France.
38
Hôpital Necker, Paris, France.
39
Hôpital A. Michallon, Grenoble, France.
40
Hôpital la Pitié Salpêtrière, Paris, France.
41
CH Victor Dupouy, Argenteuil, France.
42
CHU Hôpital Nord, Saint-Etienne, France.
43
CHU Hôpital Nord, Amiens, France.
44
CH Alpes-Leman, Contamine sur Avre, France.
45
CHU Grenoble, Grenoble, France.
46
Hôpital du Bocage, CHU de Dijon, France.
47
Clinique Mutualiste des Eaux Claires, Grenoble, France.
48
Hôpital Saint Louis, Paris, France.
49
Hôpital Charles-Nicolle, Rouen, France.
50
CHU de Lyon, France.
51
Hôpital Jean Minjoz, Besançon, France.
52
Hôpital Gui de Chauliac, Montpellier, France.
53
Hôpital des Enfants, Toulouse, France.
54
Hôpital Antoine Beclère, Clamart, France.
55
Hôpital de Givors, Givors, France.
56
CHU de Montpellier, France.
57
CHU de Strasbourg, France.
58
Hôpital Pontchaillou, Rennes, France.
59
Groupe Hospitalier Le Creusot-Montceau, Le Creusot, France.
60
Hôpital Saint Joseph, Marseille, France.
61
Hôpital Trousseau, Paris, France.
62
CHU de Lille, France.
63
CH d'Annecy, France.
64
Hôpital Civil, Strasbourg, France.
65
CHU de Rennes, France.
66
CH Cambrai, Cambrai, France.
67
Hospices Civils de Lyon, Lyon, France.
68
GHM Les portes du Sud, Venissieux, France.
69
Clinique Universitaire de Pédiatrie, Grenoble, France.
70
CHU Avicenne, Bobigny, France.
71
Hôpital de la Conception, Marseille, France.
72
Hôpital Bretonneau, Tours, France.
73
CHU Nancy, Vandoeuvre-Les-Nancy, France.
74
CHU de Grenoble, Echirolles, France.
75
Hôpital Privé Sévigne, Cesson-Sevigne, France.
76
CHU Lariboisière, Paris, France.
77
CHI Villeneuve Saint Georges, Villeneuve Saint Georges, France.
78
CHU de Dijon, France.
79
CHU de Chambéry, France.
80
CH Sud Francilien, Evry, France.
81
Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
82
Hôpital Victor Provot, Roubaix, France.
83
CH Haguenau, Haguenau, France.
84
Private Pratice, Aix en Provence, France.
85
CHI de Poissy, France.
86
CH de Lagny, France.
87
Private Practice, Marmande, France.
88
Hôpital Général de la Fontaine, Saint Denis, France.
89
Private Practice, Poitiers, France.
90
CHRU Arnaud de Villeneuve, Montpellier, France.
91
Hôpital Cochin, Paris, France.
92
CH de Langres, France.
93
CHU de Brest, France.
94
Hôpital Avicenne, Bobigny, France.
95
CHU Caremeau, Nîmes, France.
96
Hôpital Sainte Musse, Toulon, France.
97
Hôpital Simone Veil, Montmorency, France.
98
CH Lucien Hussel, Vienne, France.
99
Hôpital Robert Debré, Paris, France.
100
Pasteur Institute, Nice, France.
101
Clinique Stella, Montpellier, France.
102
CHU du Mans, France.
103
CH de Cholet, Cholet, France.
104
CHU de Limoges, France.
105
CH Saint-Dié des Vosges, Saint-Dié, France.
106
CHU La Miletrie, Poitiers, France.
107
CHU de Bordeaux, France.
108
Hôpital Garderose, Libourne, France.
109
Hôpital Jeanne de Flandre, Lille, France.
110
CH Chalon sur saone, Chalon sur Saone, France.
111
CH de Saintonge, Saintes, France.
112
CH le Rouvray, Sotteville-les-Rouen, France.
113
Private Practice, Aix en Provence, France.
114
CHU d'Angers, France.
115
CHRU Roger Salengro, Lille, France.
116
Hôpital Bellevue, Saint-Etienne, France.
117
CH de Laval, France.
118
Hôpital de la Timone, Marseille, France.
119
Hôpital Tenon, Paris, France.
120
Hôpital Lapeyronie, Montpellier, France.
121
CH Drome Nord, Romans sur Isère, France.
122
CH Moulins, Moulins, France.
123
Private Pratice, Vitrolles, France.
124
CHU Cavale Blanche, Brest, France.
125
Hôpital Max Fourestier, Nanterre, France.
126
Private Practice, Strasbourg, France.
127
Hôpital Sainte Marguerite, Marseille, France.
128
Private Practice, Marignane, France.
129
Hôpital Pierre Wertheimer, Lyon, France.
130
Hôpital Haut-Lévêque, Pessac, France.
131
CH Valence, Valence, France.

Abstract

BACKGROUND:

Safety of HPV vaccines is still in question due to reports of autoimmune diseases (ADs) following HPV immunization.

OBJECTIVES:

To assess the risk of ADs associated with HPV vaccination of female adolescents/young adults in France.

METHODS:

Systematic prospective case-referent study conducted to assess the risks associated with real-life use of HPV vaccines. Cases were female 11-25 years old with incident ADs [central demyelination/multiple sclerosis (CD/MS), connective tissue disease (CTD), Guillain-Barré syndrome (GBS), type-1 diabetes (T1D), autoimmune thyroiditis (AT), and idiopathic thrombocytopenic purpura (ITP)]. Cases were consecutively and prospectively identified at specialized centers across France (2008-2014) and individually matched by age and place of residence to referents recruited in general practice. Risk was computed using multivariate conditional logistic regression models adjusted for family history of ADs, living in France (north/south), co-medications and co-vaccinations.

RESULTS:

With a total of 478 definite cases matched to 1869 referents, all ADs combined were negatively associated to HPV vaccination with an adjusted odds ratio of 0.58 (95% confidence interval: 0.41-0.83). Similar results were obtained for CD/MS, AT, CT, and T1D, the last two not reaching statistical significance. No association was found for ITP and GBS. Sensitivity analyses combining definite and possible cases with secondary time window showed similar results.

CONCLUSION:

Exposure to HPV vaccines was not associated with an increased risk of ADs within the time period studied. Results were robust to case definitions and time windows of exposure. Continued active surveillance is needed to confirm this finding for individual ADs.

KEYWORDS:

Autoimmune disease; HPV vaccine; Pharmacoepidemiology

PMID:
28190705
DOI:
10.1016/j.jaut.2017.01.005
[Indexed for MEDLINE]
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