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Environ Pollut. 2017 Apr;223:695-704. doi: 10.1016/j.envpol.2017.02.005. Epub 2017 Feb 10.

Short-term effects of particle size fractions on circulating biomarkers of inflammation in a panel of elderly subjects and healthy young adults.

Author information

1
Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran; Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
2
Department of Research Methodology and Data Analysis, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran.
3
Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
4
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute (Swiss TPH), Basel, Switzerland; University of Basel, Basel, Switzerland.
5
Department of Environmental Health Engineering, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
6
Department of Environmental Health Engineering, School of Public Health, Tabriz University of Medical Sciences, Tabriz, Iran.
7
Department of Civil Engineering, Sharif University of Technology, Tehran, Iran.
8
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
9
Department of Environmental Health Engineering, School of Public Health, Shiraz University of Medical Sciences, Fars, Iran.
10
Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran; Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: hassanvand@tums.ac.ir.

Abstract

Systemic inflammation biomarkers have been associated with risk of cardiovascular morbidity and mortality. We aimed to clarify associations of acute exposure to particulate matter (PM10 (PM < 10 μm), PM2.5-10 (PM 2.5-10 μm), PM2.5 (PM < 2.5 μm), PM1-2.5 (PM 1-2.5 μm), and PM1 (PM < 1 μm)) with systemic inflammation using panels of elderly subjects and healthy young adults. We followed a panel of 44 nonsmoking elderly subjects living in a retirement home and a panel of 40 healthy young adults living in a school dormitory in Tehran city, Iran from May 2012 to May 2013. Blood biomarkers were measured one every 7-8 weeks and included white blood cells (WBC), high sensitive C-reactive protein (hsCRP), tumor necrosis factor-soluble receptor-II (sTNF-RII), interleukin-6 (IL-6), and von Willebrand factor (vWF). We measured hourly indoor and outdoor exposure to PM10, PM2.5-10, PM2.5, PM1-2.5, and PM1 mass concentration to derive weighted averages of personal exposure based on simultaneously collected time-activity data. The random intercept linear mixed effects model was used for data analysis. We observed significant positive associations for WBC and IL-6 with exposure to PM10, PM2.5-10, PM2.5, PM1-2.5, and PM1; sTNF-RII with PM2.5, PM1-2.5, and PM1; hsCRP with PM2.5 and PM1; and vWF with PM10 and PM2.5-10, PM2.5, and PM1-2.5 mass concentration in elderly subjects from the current-day and multiday averages. For healthy young adults, we found significant positive associations for WBC and IL-6 with exposure to PM10, PM2.5-10, PM2.5, and PM1-2.5, but no with PM1. The results showed that increase of hsCRP, sTNF-RII, and vWF were not significantly associated with any of the PM sizes investigated in the healthy young subjects. Our results provided some evidence that short-term exposure to PM10, PM2.5-10, PM2.5, PM1-2.5, and PM1 was associated with inflammation and coagulation blood markers, but associations were depended on PM size and also differed across the various time lag.

KEYWORDS:

Circulating biomarkers; Elderly panel; Healthy young panel; Particulate matter

PMID:
28190687
DOI:
10.1016/j.envpol.2017.02.005
[Indexed for MEDLINE]

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