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Clin Ther. 2017 Mar;39(3):659-660. doi: 10.1016/j.clinthera.2017.01.029. Epub 2017 Feb 9.

Lipid-lowering Therapy in Patients With High Cardiovascular Risk: Dose or Combination?

Author information

1
Department of Clinical Research, Federal University of Uberlândia, Uberlândia, Brazil. Electronic address: leonardoroever@hotmail.com.
2
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy; Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.
3
Duke Clinical Research Institute, Durham, North Carolina.

Abstract

Cardiovascular disease is the leading cause of death in the world. Dyslipidemia, manifested by elevated low-density lipoprotein cholesterol (LDL-C) levels, is central to the development and progression of atherosclerosis. Dyslipidemia has become a primary target of intervention in strategies for the prevention of cardiovascular events. Therapeutic lifestyle changes, such as increased physical activity, weight loss, smoking cessation, and adoption of a healthier diet, are effectively reducing cardiovascular risk in primary and secondary prevention. The combination therapy lowered LDL-C levels and achieved the LDL-C target in patients with high cardiovascular risk.

KEYWORDS:

cardiovascular risk; dyslipidemia; lipids; statins

PMID:
28190598
DOI:
10.1016/j.clinthera.2017.01.029
[Indexed for MEDLINE]
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