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Exp Gerontol. 2017 May;91:9-14. doi: 10.1016/j.exger.2017.02.002. Epub 2017 Feb 9.

Skin autofluorescence is associated with arterial stiffness and insulin level in endurance runners and healthy controls - Effects of aging and endurance exercise.

Author information

1
Department of Physical Therapy, Bispebjerg Hospital, University of Copenhagen, Denmark; IOC Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: ccouppe@gmail.com.
2
Department of Physical Therapy, Bispebjerg Hospital, University of Copenhagen, Denmark; IOC Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
3
IOC Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
4
Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
5
Department of Sports Medicine, Australian Institute of Sport, Canberra, Australia.
6
Department of Physical Therapy, Bispebjerg Hospital, University of Copenhagen, Denmark; IOC Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Abstract

BACKGROUND:

Life-long regular endurance exercise yields positive effects on cardiovascular and metabolic function, disease and mortality rate. Glycation may be a major mechanism behind age-related diseases. However, it remains unknown if skin autofluorescence (SAF), which reflects glycation, is related to arterial and metabolic function in life-long endurance runners and sedentary controls.

METHODS:

Healthy elderly men: 15 life-long endurance runners (OT) (64±4years) and 12 old untrained (OU) (66±4years), and healthy young men; ten young athletes (YT) (26±4years) matched to OT for running distance, and 12 young untrained (YU) (24±3years) were recruited. Endothelial function (reactive hyperemia index, RHI) and arterial stiffness (augmentation index, AI@75 and AI) were measured by an operator-independent PAT 2000. SAF was non-invasively determined using an autofluorescence spectrometer.

RESULTS:

For AI@75 there was an effect of age (p<0.0001), but not training (p=0.71). There was an interaction for endothelial function (p<0.05): YT had higher RHI than YU (p<0.05) and OU (p<0.01). SAF was associated with arterial stiffness (r2=0.57, p<0.001), insulin and HOMA-index levels after age correction (both r2=0.19, p<0.05).

CONCLUSIONS:

To our knowledge, these are the first data to show that skin autofluorescence (SAF) is linked to human arterial stiffness and insulin resistance in well-trained elderly and young men as well as sedentary controls. SAF may in the future be a helpful tool to predict vascular and metabolic dysfunction (early signs of aging and pathology). Surprisingly, endurance running only had modest effects on cardiovascular function compared to lean healthy controls.

KEYWORDS:

Aging; Endothelial function; Glycation; Running; Skin autofluorescence; Vascular stiffness

PMID:
28189699
DOI:
10.1016/j.exger.2017.02.002
[Indexed for MEDLINE]

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