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Schizophr Res. 2017 Dec;190:52-59. doi: 10.1016/j.schres.2017.02.002. Epub 2017 Feb 9.

The coupling of low-level auditory dysfunction and oxidative stress in psychosis patients.

Author information

1
Neuropsychology and Neurorehabilitation Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; Radiodiagnostic Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland.
2
Neuropsychology and Neurorehabilitation Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland.
3
Neuropsychology and Neurorehabilitation Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; Radiodiagnostic Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; The EEG Brain Mapping Core, Center for Biomedical Imaging (CIBM), University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland.
4
Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland; Service of General Psychiatry, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland.
5
Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland.
6
Center for Psychiatric Neuroscience, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland; Service of General Psychiatry, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland; Psychiatric Liaison Service, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
7
Service of General Psychiatry, Department of Psychiatry, University Hospital Center and University of Lausanne, Prilly-Lausanne, Switzerland.
8
Neuropsychology and Neurorehabilitation Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; Radiodiagnostic Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; The EEG Brain Mapping Core, Center for Biomedical Imaging (CIBM), University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; Psychiatric Liaison Service, Lausanne University Hospital (CHUV), Lausanne, Switzerland; Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Lausanne, Switzerland; Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN, USA. Electronic address: micah.murray@chuv.ch.

Abstract

Patients diagnosed with schizophrenia often present with low-level sensory deficits. It is an open question whether there is a functional link between these deficits and the pathophysiology of the disease, e.g. oxidative stress and glutathione (GSH) metabolism dysregulation. Auditory evoked potentials (AEPs) were recorded from 21 psychosis disorder patients and 30 healthy controls performing an active, auditory oddball task. AEPs to standard sounds were analyzed within an electrical neuroimaging framework. A peripheral measure of participants' redox balance, the ratio of glutathione peroxidase and glutathione reductase activities (GPx/GR), was correlated with the AEP data. Patients displayed significantly decreased AEPs over the time window of the P50/N100 complex resulting from significantly weaker responses in the left temporo-parietal lobe. The GPx/GR ratio significantly correlated with patients' brain activity during the time window of the P50/N100 in the medial frontal lobe. We show for the first time a direct coupling between electrophysiological indices of AEPs and peripheral redox dysregulation in psychosis patients. This coupling is limited to stages of auditory processing that are impaired relative to healthy controls and suggests a link between biochemical and sensory dysfunction. The data highlight the potential of low-level sensory processing as a trait-marker of psychosis.

KEYWORDS:

Auditory; Event-related potential (ERP); Glutathione (GSH); Oxidative stress; Psychosis; Schizophrenia

PMID:
28189532
DOI:
10.1016/j.schres.2017.02.002
[Indexed for MEDLINE]
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