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Clin Nutr. 2018 Apr;37(2):597-603. doi: 10.1016/j.clnu.2017.01.013. Epub 2017 Jan 29.

Dietary acid load and blood pressure development in pregnancy: The Generation R Study.

Author information

1
Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. Electronic address: m.tielemans@erasmusmc.nl.
2
Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; Department of Biostatistics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
3
Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
4
Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
5
Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
6
Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; Leiden University College, The Hague, The Netherlands.

Abstract

BACKGROUND & AIMS:

Dietary intake could induce a mild maternal metabolic acidosis that might lead to a higher level of blood pressure. Because studies in pregnancy are scarce, we evaluated the association between maternal dietary acid load and changes in blood pressure during pregnancy, pregnancy-induced hypertension and pre-eclampsia.

METHODS:

We included 3411 pregnant women of Dutch ancestry from a prospective population-based cohort (Rotterdam, The Netherlands). Dietary data was self-reported via a food-frequency questionnaire in early pregnancy. Four dietary acid load measurements were calculated: dietary potential renal acid load (dPRAL), net endogenous acid production (NEAP), animal protein/potassium ratio, and vegetable protein/potassium ratio. Diastolic blood pressure (DBP) and systolic blood pressure (SBP) were measured three times during pregnancy. Information on pregnancy-induced hypertension and pre-eclampsia was obtained from medical records. Linear mixed models and logistic regression were used and adjusted for sociodemographic and lifestyle factors.

RESULTS:

The results indicated that dPRAL, NEAP and animal protein/potassium ratio were not associated with DBP or SBP in pregnancy. One standard deviation higher vegetable protein/potassium ratio was associated with lower DBP (-0.30 mmHg [95% CI -0.54; -0.06]) but not with SBP (-0.29 mmHg [95% CI -0.60; 0.01]). Dietary acid load measurement was neither associated with the prevalence of pregnancy-induced hypertension nor with pre-eclampsia.

CONCLUSIONS:

Dietary acid load was not associated with changes in DBP or SBP during pregnancy, although women with a higher vegetable protein/potassium ratio had a slightly lower DBP. Dietary acid load was not associated with pregnancy-induced hypertension or pre-eclampsia.

KEYWORDS:

Blood pressure; Dietary acid load; Dietary intake; Pre-eclampsia; Pregnancy

PMID:
28189385
DOI:
10.1016/j.clnu.2017.01.013

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