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Neurotoxicology. 2017 May;60:125-133. doi: 10.1016/j.neuro.2017.02.002. Epub 2017 Feb 7.

Potential short-term neurobehavioral alterations in children associated with a peak pesticide spray season: The Mother's Day flower harvest in Ecuador.

Author information

1
Division of Global Health, Department of Family Medicine and Public Health, University of California, San Diego, 9500 Gilman Drive #0725, La Jolla, CA 92024-0725, USA; Fundacion Cimas del Ecuador, De los Olivos E14-226 y las Minas, Quito, Pichincha, Ecuador. Electronic address: jrsuarez@ucsd.edu.
2
Division of Global Health, Department of Family Medicine and Public Health, University of California, San Diego, 9500 Gilman Drive #0725, La Jolla, CA 92024-0725, USA. Electronic address: hcheckoway@ucsd.edu.
3
Division of Epidemiology and Community Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454, USA. Electronic address: jacob004@umn.edu.
4
Division of Global Health, Department of Family Medicine and Public Health, University of California, San Diego, 9500 Gilman Drive #0725, La Jolla, CA 92024-0725, USA.
5
Division of Academic General Pediatrics, Child Development and Community Health, Department of Pediatrics, University of California, 9500 Gilman Drive #0832, La Jolla, CA 92024-0832, USA. Electronic address: sgahagan@ucsd.edu.

Abstract

BACKGROUND:

Exposures to cholinesterase inhibitor pesticides (e.g. organophosphates) have been associated with children's neurobehavioral alterations, including attention deficit and impulsivity. Animal studies have observed transient alterations in neurobehavioral performance in relation to cholinesterase inhibitor pesticide exposures; however, limited evidence exists regarding transient effects in humans.

METHODS:

We estimated the associations between neurobehavioral performance and time after Mother's Day flower harvest (the end of a heightened pesticide usage period) among 308 4-to 9-year-old children living in floricultural communities in Ecuador in 2008 who participated in the ESPINA study. Children's neurobehavior was examined once (NEPSY-II: 11 subtests covering 5 domains), between 63 and 100days (SD: 10.8days) after Mother's Day harvest (blood acetylcholinesterase activity levels can take 82days to normalize after irreversible inhibition with organophosphates).

RESULTS:

The mean (SD) neurobehavioral scaled scores across domains ranged from 6.6 (2.4) to 9.9 (3.3); higher values reflect greater performance. Children examined sooner after Mother's Day had lower neurobehavioral scores than children examined later, in the domains of (score difference per 10.8days, 95%CI): Attention/Inhibitory Control (0.38, 0.10-0.65), Visuospatial Processing (0.60, 0.25-0.95) and Sensorimotor (0.43, 0.10-0.77). Scores were higher with longer time post-harvest among girls (vs. boys) in Attention/Inhibitory Control.

CONCLUSIONS:

Our findings, although cross-sectional, are among the first in non-worker children to suggest that a peak pesticide use period may transiently affect neurobehavioral performance, as children examined sooner after the flower harvest had lower neurobehavioral performance than children examined later. Studies assessing pre- and post-exposure measures are needed.

KEYWORDS:

Acute; Children; Cholinesterase; Neurobehavior; Pesticides; Transient

PMID:
28188819
PMCID:
PMC5447476
DOI:
10.1016/j.neuro.2017.02.002
[Indexed for MEDLINE]
Free PMC Article

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