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Ophthalmology. 2017 May;124(5):697-700. doi: 10.1016/j.ophtha.2017.01.006. Epub 2017 Feb 7.

Re-evaluating the Incidence of Idiopathic Intracranial Hypertension in an Era of Increasing Obesity.

Author information

1
College of Medicine, Mayo Clinic, Jacksonville, Florida; Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida.
2
Department of Neuro-Ophthalmology, University of Minnesota, Minneapolis, Minnesota.
3
Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida.
4
Department of Neurology, Mayo Clinic, Jacksonville, Florida.
5
Department of Health Sciences Research/Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida.
6
Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida. Electronic address: chen.john@mayo.edu.

Abstract

PURPOSE:

To re-evaluate the population-based incidence of idiopathic intracranial hypertension (IIH) and to determine if it mirrors the rise in obesity.

DESIGN:

Retrospective, population-based cohort.

PARTICIPANTS:

All residents of Olmsted County, Minnesota, diagnosed with IIH between January 1, 1990, and December 31, 2014.

METHODS:

All cases of IIH were identified using the Rochester Epidemiology Project, which is a record-linkage system of medical records for all patient-physician encounters among Olmsted County, Minnesota, residents. All medical records were reviewed to confirm a diagnosis of IIH. The incidence rates of IIH were compared against the incidence of obesity in Minnesota over the same period.

MAIN OUTCOME MEASURES:

Incidence of IIH, lumbar puncture opening pressures, and body mass index.

RESULTS:

There were 63 new cases of IIH, yielding an overall age- and gender-adjusted annual incidence of 1.8 per 100 000 (95% confidence interval, 1.3-2.2) between 1990 and 2014. It increased from 1.0 per 100 000 (1990-2001) to 2.4 per 100 000 (2002-2014; P = 0.007). The incidence of IIH was 3.3 per 100 000 in women and 0.3 per 100 000 in men (P ≤ 0.001). In obese women 15 to 44 years of age, the incidence was 22.0 per 100 000 compared with 6.8 per 100 000 among all women in the same age group. A strong correlation was observed between IIH incidence rates and obesity rates in Minnesota (R2 = 0.70, P = 0.008).

CONCLUSIONS:

The incidence of IIH has increased since 1990, which is highly correlated with the rise in obesity during the same period.

PMID:
28187976
PMCID:
PMC5637544
DOI:
10.1016/j.ophtha.2017.01.006
[Indexed for MEDLINE]
Free PMC Article

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