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Int J Cancer. 2017 May 1;140(9):2060-2069. doi: 10.1002/ijc.30642. Epub 2017 Feb 22.

Dairy intake in relation to prostate cancer survival.

Author information

1
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
2
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
3
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
4
Department of Medicine and the Meyers Primary Care Institute, University of Massachusetts Medical School, Worcester, MA.
5
The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
6
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
7
Department of Urology, Örebro University Hospital, Örebro, Sweden.

Abstract

Dairy intake has been associated with increased risk of advanced prostate cancer. Two US cohort studies reported increased prostate cancer-specific mortality with increased high-fat milk intake. We examined whether dairy and related nutrient intake were associated with prostate cancer progression in a Swedish patient population with high dairy consumption. We prospectively followed 525 men with newly diagnosed prostate cancer (diagnosed 1989-1994). We identified and confirmed deaths through February 2011 (n = 222 prostate cancer-specific, n = 268 from other causes). Cox proportional hazards regression was used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for the associations between food or nutrient intake and prostate cancer-specific death. On average, patients consumed 5.0 servings/day of total dairy products at diagnosis. In the whole population, high-fat milk intake was not associated with prostate cancer-specific death (95% CI: 0.78, 2.10; p-trend = 0.32; multivariate-adjusted model). However, among patients diagnosed with localized prostate cancer, compared to men who consumed <1 servings/day of high-fat milk, those who drank ≥3 servings/day had an increased hazard of prostate cancer mortality (HR = 6.10; 95% CI: 2.14, 17.37; p-trend = 0.004; multivariate-adjusted model). Low-fat milk intake was associated with a borderline reduction in prostate cancer death among patients with localized prostate cancer. These associations were not observed among patients diagnosed with advanced stage prostate cancer. Our data suggest a positive association between high-fat milk intake and prostate cancer progression among patients diagnosed with localized prostate cancer. Further studies are warranted to investigate this association and elucidate the mechanisms by which high-fat milk intake may promote prostate cancer progression.

KEYWORDS:

dairy; diet; milk; prostate cancer; prostate cancer mortality

PMID:
28187509
DOI:
10.1002/ijc.30642
[Indexed for MEDLINE]
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