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Curr Opin Biotechnol. 2017 Aug;46:51-56. doi: 10.1016/j.copbio.2016.10.012. Epub 2017 Feb 7.

Synthetic (polymer) biology (membrane): functionalization of polymer scaffolds for membrane proteins.

Author information

1
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Drive, 637553, Singapore.
2
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Drive, 637553, Singapore; ACM Biolabs Pte Ltd., Innovation Centre Block 2, 18 Nanyang Drive, 637723, Singapore. Electronic address: MNallani@ntu.edu.sg.

Abstract

A plethora of polymer-based scaffolds have been designed to facilitate biochemical and biophysical investigation of membrane proteins, with a common goal to stabilize and present them in a functional format. In this review, an up-to-date account of such polymer-based supports and incorporation methodologies are presented. Furthermore, conceptual and imminent technological advances, with associated technical challenges are proposed.

PMID:
28187339
DOI:
10.1016/j.copbio.2016.10.012
[Indexed for MEDLINE]

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