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Cell. 2017 Feb 9;168(4):670-691. doi: 10.1016/j.cell.2016.11.037.

Emerging Biological Principles of Metastasis.

Author information

1
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
2
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology and the MIT Ludwig Center for Molecular Oncology, Cambridge, MA 02142, USA. Electronic address: weinberg@wi.mit.edu.

Abstract

Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and we highlight the general principles of metastasis that have begun to emerge.

PMID:
28187288
PMCID:
PMC5308465
DOI:
10.1016/j.cell.2016.11.037
[Indexed for MEDLINE]
Free PMC Article

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