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Cell. 2017 Feb 9;168(4):657-669. doi: 10.1016/j.cell.2016.12.039.

Understanding the Intersections between Metabolism and Cancer Biology.

Author information

1
The Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address: mvh@mit.edu.
2
Children's Medical Center Research Institute, Department of Pediatrics, and Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX 75390. Electronic address: ralph.deberardinis@utsouthwestern.edu.

Abstract

Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.

PMID:
28187287
PMCID:
PMC5329766
DOI:
10.1016/j.cell.2016.12.039
[Indexed for MEDLINE]
Free PMC Article

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