Format

Send to

Choose Destination
Adv Mater. 2017 Apr;29(15). doi: 10.1002/adma.201605235. Epub 2017 Feb 10.

A Difunctional Regeneration Scaffold for Knee Repair based on Aptamer-Directed Cell Recruitment.

Author information

1
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
2
State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
3
Medical Research Institute, School of Medicine, Wuhan University, Wuhan, 430071, China.

Abstract

To solve the challenge of poor knee repair, an aptamer-bilayer scaffold is designed for autologous mesenchymal stem cell (MSC) recruitment and osteochondral regeneration. The scaffold can efficiently recruit MSCs to the defect and induce the directional differentiation of MSCs, thus successfully achieving simultaneous regeneration of cartilage and bone in the knee joint.

KEYWORDS:

aptamers; cell recruitment; knee repair; osteochondral defect; scaffolds

PMID:
28185322
DOI:
10.1002/adma.201605235
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center