Format

Send to

Choose Destination
BMC Cardiovasc Disord. 2017 Feb 10;17(1):57. doi: 10.1186/s12872-017-0489-2.

Association in a Chinese population of a genetic variation in the early B-cell factor 1 gene with coronary artery disease.

Author information

1
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Gu Lou Area, Nanjing, 210029, China.
2
Department of Cardiology, Xuzhou Medical University, NO.209 Tongshan Road, Xuzhou, 221000, China.
3
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Gu Lou Area, Nanjing, 210029, China. drlswang@njmu.edu.cn.
4
Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital East Campus, No. 222 Huanhu Xisan Road, Pudong New Area, Shanghai, 201306, China. zhongchen7498@hotmail.com.

Abstract

BACKGROUND:

Early B-cell factor 1 (EBF1) is a transcription factor expressed primarily during early B cell development. Previous studies have shown EBF1 regulates blood glucose and lipid metabolism in mice with diabetes and central adiposity. Recently, a genetic variation (rs36071027) located in an EBF1 gene intron was associated with carotid artery intima-media thickness. However, whether this polymorphism is actually linked with coronary artery disease (CAD) and its severity remains unclear.

METHODS:

This study includes 293 CAD cases and 262 controls without CAD. All participants were devided into two groups based on their coronary angiography results. A polymerase chain reaction-ligase detection reaction was used to identify genotypes at rs36071027, and CAD patients were further divided into subgroups with one-, two-, or three-vessel stenosis reflective of CAD severity.

RESULTS:

The frequency of the rs36071027 TT genotype was significantly higher in CAD cases versus controls (4.8% vs. 1.5%, 95% CI: 1.13-10.81 P = 0.029). Subjects with a variant genotype T allele had an increased risk of CAD compared to C allele carriers (additive model: 95% CI: 1.13-2.23, P = 0.008). After adjustment for cardiovascular risk factors, analysis of the additive and dominant models involving rs36071027 also revealed that T allele carriers had a significantly higher risk for CAD than C allele carriers (additive model: OR 1.56, 95% CI 1.10-2.22, P = 0.013; dominant model: OR 1.60, 95% CI 1.07-2.41, P = 0.023). Furthermore, both diabetes and the CT + TT rs36071027 genotype were significantly associated with three-vessel stenosis.

CONCLUSION:

Our results in a Chinese population suggest that the TT genotype and T alleles in rs36071027 in the EBF1 gene are associated with an increased risk of CAD and its severity.

KEYWORDS:

Coronary artery disease; Early B-cell factor 1; Genetic polymorphism; Risk assessment

PMID:
28183271
PMCID:
PMC5301365
DOI:
10.1186/s12872-017-0489-2
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center