Format

Send to

Choose Destination
Cell Host Microbe. 2017 Feb 8;21(2):244-253. doi: 10.1016/j.chom.2017.01.010.

Conserved Fever Pathways across Vertebrates: A Herpesvirus Expressed Decoy TNF-α Receptor Delays Behavioral Fever in Fish.

Author information

1
Immunology-Vaccinology, FARAH, Faculty of Veterinary Medicine, University of Liège, Liège 4000, Belgium; Department of Evolutionary Immunology, Institute of Zoology, Jagiellonian University, Krakow 30-387, Poland.
2
Immunology-Vaccinology, FARAH, Faculty of Veterinary Medicine, University of Liège, Liège 4000, Belgium.
3
Cell Biology and Immunology Group, Department of Animal Sciences, Wageningen University and Research, Wageningen 6708WD, the Netherlands.
4
Immunology-Vaccinology, FARAH, Faculty of Veterinary Medicine, University of Liège, Liège 4000, Belgium; Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice 44-101, Poland.
5
Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YW, UK.
6
Instituto Gulbenkian de Ciência, Oeiras 2781-156, Portugal.
7
Biostatistics and Bioinformatics, FARAH, University of Liège, Liège 4000, Belgium.
8
MRC - University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK.
9
Virologie et Immunologie Moléculaires, INRA, Jouy-en-Josas 78352, France.
10
de Duve Institute, Université Catholique de Louvain, Brussels 1200, Belgium.
11
Immunology-Vaccinology, FARAH, Faculty of Veterinary Medicine, University of Liège, Liège 4000, Belgium. Electronic address: a.vdplasschen@ulg.ac.be.

Abstract

Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving to warmer places, hence the term "behavioral fever." We studied the manifestation of behavioral fever in the common carp infected by cyprinid herpesvirus 3, a native carp pathogen. Carp maintained at 24°C died from the infection, whereas those housed in multi-chamber tanks encompassing a 24°C-32°C gradient migrated transiently to the warmest compartment and survived as a consequence. Behavioral fever manifested only at advanced stages of infection. Consistent with this, expression of CyHV-3 ORF12, encoding a soluble decoy receptor for TNF-α, delayed the manifestation of behavioral fever and promoted CyHV-3 replication in the context of a temperature gradient. Injection of anti-TNF-α neutralizing antibodies suppressed behavioral fever, and decreased fish survival in response to infection. This study provides a unique example of how viruses have evolved to alter host behavior to increase fitness.

KEYWORDS:

behavioral fever; cyprinid herpesvirus 3; fever; herpesvirus; host-virus interactions; immune evasion mechanisms; innate immunity; pathogen-host-environment interplay; tumor necrosis factor α; viral decoy receptor for cytokine

PMID:
28182952
PMCID:
PMC5301049
DOI:
10.1016/j.chom.2017.01.010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center