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Cell Host Microbe. 2017 Feb 8;21(2):127-129. doi: 10.1016/j.chom.2017.01.014.

Strange New World: Bacteria Catalyze Ubiquitylation via ADP Ribosylation.

Author information

1
MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address: dk@mrc-lmb.cam.ac.uk.
2
MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Francis Crick Avenue, Cambridge CB2 0QH, UK; University of Cambridge, Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address: randow@mrc-lmb.cam.ac.uk.

Abstract

Three recent papers, including one by Kotewicz et al. (2016) in this issue of Cell Host & Microbe, show that Legionella deploys a novel form of ubiquitylation to generate its replicative vacuole. Without E1 and E2 enzymes, SidE effectors ubiquitylate serine residues in substrates via an ADP-ribosylated ubiquitin intermediate.

PMID:
28182945
DOI:
10.1016/j.chom.2017.01.014
[Indexed for MEDLINE]
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