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Neuron. 2017 Feb 8;93(3):470-472. doi: 10.1016/j.neuron.2017.01.024.

One Cycle Fuels Another: The Energetics of Neurotransmitter Release.

Author information

1
Kavli Institute for Fundamental Neuroscience, UCSF Weill Institute for Neurosciences, University of California, San Francisco, 600 16th Street, GH-N272B, San Francisco, CA 94143, USA; Departments of Neurology and Physiology, UCSF School of Medicine, University of California, San Francisco, 600 16th Street, GH-N272B, San Francisco, CA 94143, USA.
2
Kavli Institute for Fundamental Neuroscience, UCSF Weill Institute for Neurosciences, University of California, San Francisco, 600 16th Street, GH-N272B, San Francisco, CA 94143, USA; Departments of Neurology and Physiology, UCSF School of Medicine, University of California, San Francisco, 600 16th Street, GH-N272B, San Francisco, CA 94143, USA. Electronic address: robert.edwards@ucsf.edu.

Abstract

In this issue of Neuron, Ashrafi et al. (2017) show that activity induces translocation of the insulin-regulated glucose transporter GLUT4 to the plasma membrane, where it sustains the ATP production required for synaptic vesicle cycling. However, translocation occurs from presynaptic membranes other than synaptic vesicles and involves a distinct molecular mechanism.

PMID:
28182901
DOI:
10.1016/j.neuron.2017.01.024
[Indexed for MEDLINE]
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