Anti-prediabetic effect of rose hip (Rosa canina) extract in spontaneously diabetic Torii rats

J Sci Food Agric. 2017 Sep;97(12):3923-3928. doi: 10.1002/jsfa.8254. Epub 2017 Mar 8.

Abstract

Background: Prediabetes, a high-risk state for developing diabetes showing impaired glucose tolerance but a normal fasting blood glucose level, has an increasing prevalence worldwide. However, no study investigating the prevention of impaired glucose tolerance at the prediabetic stage by anti-diabetic functional foods has been reported. Thus, the present study aimed to evaluate the anti-prediabetic effect of rose hip in a prediabetic rat model.

Results: Spontaneously diabetic Torii (SDT) rats were supplemented with hot-water extract of rose hip at a dose of 100 mg kg-1 body weight day-1 for 12 weeks. The results obtained showed that the supplementation of rose hip extract improved impaired glucose tolerance, promoted insulin secretion, preserved pancreatic beta-cell function and suppressed plasma advanced glycation end-products formation of methylglyoxal-derived hydroimidazolone (MG-H1) residue and Nϵ -carboxymethyl-lysine residues (e.g. MG-H1, control: 465.5 ± 43.8 versus rose hip: 59.1 ± 13.0 pmol mg protein-1 , P < 0.05) in SDT rats at the prediabetic stage (12-20 weeks old).

Conclusion: The present study provides the first evidence showing that a hot-water extract of rose hip could exert an anti-prediabetic effect in a rat model. © 2017 Society of Chemical Industry.

Keywords: advanced glycation end-products; anti-prediabetes; prediabetes; rose hip; spontaneously diabetic Torii rat.

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / metabolism
  • Glycation End Products, Advanced / metabolism
  • Humans
  • Hypoglycemic Agents / administration & dosage*
  • Insulin / metabolism
  • Male
  • Pancreas / metabolism
  • Plant Extracts / administration & dosage*
  • Rats
  • Rats, Sprague-Dawley
  • Rosa / chemistry*

Substances

  • Blood Glucose
  • Glycation End Products, Advanced
  • Hypoglycemic Agents
  • Insulin
  • Plant Extracts