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Nat Commun. 2017 Feb 9;8:14253. doi: 10.1038/ncomms14253.

Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement.

Author information

1
CNRS UMR-8601, Université Paris Descartes, CICB, 45 rue des Saints-Pères, 75006 Paris, France.
2
Team Chemistry &Biology, Modeling &Immunology for Therapy, CBMIT.
3
Immunoregulation Laboratory, Francis Crick Institute, London NW1 1AT, UK.
4
INSERM UMR-S 1124, Université Paris Descartes, 45 rue des Saints-Pères, 75006 Paris, France.
5
Institut Pasteur, Virus &Immunity Unit, 25-28 Rue du Dr Roux, Paris 75015, France.
6
Inflammation Chimiokines et Immunopathologie, INSERM, Faculté de médecine-Université Paris-Sud, Université Paris-Saclay, 92140 Clamart, France.
7
CNRS UMR-8147, Hôpital Necker, 156 Rue de Vaugirard, 75015 Paris, France.
8
Institut Pasteur, Unité de Régulation des Infections Rétrovirales, 25-28 Rue du Dr Roux, Paris 75015, France.
9
INSERM U1151, CNRS8253, Université Paris Descartes, Hôpital Necker, 156 Rue de Vaugirard, 75015 Paris, France.
10
Institute of Molecular Virology, Ulm University Medical Center, Ulm 89081, Germany.
11
Institut de Génomique Fonctionnelle, CNRS UMR5203, INSERM U661, Université de Montpellier (IFR3), 141 rue de la Cardonille, F-34094 Montpellier Cedex 5, France.

Abstract

Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential 'on-off' switch of pDC activity with therapeutic potential.

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