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Arch Biochem Biophys. 1989 Nov 15;275(1):244-51.

The action of free radicals on Deinococcus radiodurans carotenoids.

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1
Laboratoire de Biochimie M├ędicale A, Bordeaux, France.

Abstract

The possible role of carotenoids as free radical scavengers has not been completely elucidated. To gain further insight into the quenching of OH radicals by carotenoids, we used a feasible bacterial model, Deinococcus radiodurans, a red pigmented bacterium. We compared the action of H2O2 which produces in vivo OH radicals by a Fenton-type reaction on the parental and two mutant strains, i.e., a red pigmented and a colorless one. While the red pigmented bacteria were resistant to H2O2 action, the colorless strain was significantly more sensitive and its sensitivity was dose-dependent. In the red pigmented strains, H2O2 induced a significant decrease in one carotenoid (X5), which could be responsible for the antioxidant activity.

PMID:
2817898
[Indexed for MEDLINE]

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