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Int J Chron Obstruct Pulmon Dis. 2017 Jan 21;12:395-402. doi: 10.2147/COPD.S120445. eCollection 2017.

Factors associated with plasma IL-33 levels in patients with chronic obstructive pulmonary disease.

Author information

1
Division of Pulmonary, Department of Internal Medicine, Yeouido St Mary's Hospital.
2
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul.
3
Department of Internal Medicine, Pusan National University, School of Medicine, Busan.
4
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, St Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul.
5
Department of Internal Medicine, Soonchunhyang University Gumi Hospital, Gumi.
6
Division of Pulmonology, Department of Internal Medicine, Chonnam National University Hospital, Gwangju.
7
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine.
8
Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Abstract

BACKGROUND:

Interleukin (IL)-33 promotes T helper (Th)2 immunity and systemic inflammation. The role of IL-33 in asthma has been widely investigated. IL-33 has also been suggested to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study investigated the clinical significance and usefulness of plasma IL-33 level in patients with COPD.

METHODS:

A total of 307 patients with stable COPD from 15 centers, who were in the Korean Obstructive Lung Disease cohort, were enrolled in this study. Plasma IL-33 levels were measured by enzyme-linked immunosorbent assay. We analyzed the association between IL-33 level and other clinical characteristics related to COPD. We also examined the features of patients with COPD who exhibited high IL-33 levels.

RESULTS:

IL-33 levels varied, but were very low in most patients. Eosinophil count was significantly correlated with a plasma IL-33 level. In addition, old age and current smoking were related to a low IL-33 level. Significantly more patients with a higher IL-33 level had chronic bronchitis compared with those with a low IL-33 level.

CONCLUSION:

Plasma IL-33 level in patients with stable COPD was related to eosinophil count and chronic bronchitis phenotype. Further studies are needed to identify the precise mechanisms of IL-33/ST2 pathway in patients with COPD.

KEYWORDS:

biomarker; chronic bronchitis; cytokine; eosinophil; interleukin-33; pathogenesis

PMID:
28176939
PMCID:
PMC5268328
DOI:
10.2147/COPD.S120445
[Indexed for MEDLINE]
Free PMC Article

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