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BMC Anesthesiol. 2017 Feb 7;17(1):21. doi: 10.1186/s12871-017-0312-8.

A clinical score to predict mortality in septic acute kidney injury patients requiring continuous renal replacement therapy: the HELENICC score.

Author information

1
Hospital Português, Salvador, Brazil. oiregorpassos@yahoo.com.br.
2
Hospital São Rafael, Salvador, Brazil. oiregorpassos@yahoo.com.br.
3
Hospital São Rafael, Salvador, Brazil.
4
Hospital Português, Salvador, Brazil.
5
Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Abstract

BACKGROUND:

This study aimed to identify predictors of early (7-day) mortality in patients with septic acute kidney injury (AKI) who required continuous renal replacement therapy (CRRT).

METHODS:

Prospective cohort of 186 septic AKI patients undergoing CRRT at a tertiary hospital, from October 2005 to November 2010.

RESULTS:

After multivariate adjustment, five variables were associated to early mortality: norepinephrine utilization, liver failure, medical condition, lactate level, and pre-dialysis creatinine level. These variables were combined in a score, which demonstrated good discrimination, with a C-statistic of 0.82 (95% CI = 0.76-0.88), and good calibration (χ 2 = 4.3; p = 0.83). SAPS 3, APACHE II and SOFA scores demonstrated poor performance in this population.

CONCLUSIONS:

The HEpatic failure, LactatE, NorepInephrine, medical Condition, and Creatinine (HELENICC) score outperformed tested generic models. Future studies should further validate this score in different cohorts.

KEYWORDS:

7-day mortality; Hemodiafiltration; Risk score; Septic acute kidney injury

PMID:
28173756
PMCID:
PMC5297177
DOI:
10.1186/s12871-017-0312-8
[Indexed for MEDLINE]
Free PMC Article

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