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Clin Exp Vaccine Res. 2017 Jan;6(1):4-14. doi: 10.7774/cevr.2017.6.1.4. Epub 2017 Jan 25.

Enterovirus 71 infection and vaccines.

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Laboratory of Microbiology, College of Pharmacy, Ajou University, Suwon, Korea.
Laboratory of Microbiology, College of Pharmacy, Ajou University, Suwon, Korea.; Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon, Korea.


Hand, foot and mouth disease (HFMD) is a highly contagious viral infection affecting young children during the spring to fall seasons. Recently, serious outbreaks of HFMD were reported frequently in the Asia-Pacific region, including China and Korea. The symptoms of HFMD are usually mild, comprising fever, loss of appetite, and a rash with blisters, which do not need specific treatment. However, there are uncommon neurological or cardiac complications such as meningitis and acute flaccid paralysis that can be fatal. HFMD is most commonly caused by infection with coxsackievirus A16, and secondly by enterovirus 71 (EV71). Many other strains of coxsackievirus and enterovirus can also cause HFMD. Importantly, HFMD caused by EV71 tends to be associated with fatal complications. Therefore, there is an urgent need to protect against EV71 infection. Development of vaccines against EV71 would be the most effective approach to prevent EV71 outbreaks. Here, we summarize EV71 infection and development of vaccines, focusing on current scientific and clinical progress.


Animal models; Enterovirus 71; Hand; VP1; Vaccine; foot and mouth disease

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No potential conflict of interest relevant to this article was reported.

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