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Elife. 2017 Feb 7;6. pii: e20156. doi: 10.7554/eLife.20156.

Generation of shape complexity through tissue conflict resolution.

Author information

1
Department of Cell and Developmental Biology, John Innes Centre, Norwich, England.
2
School of Computational Sciences, University of East Anglia, Norwich, England.

Abstract

Out-of-plane tissue deformations are key morphogenetic events during plant and animal development that generate 3D shapes, such as flowers or limbs. However, the mechanisms by which spatiotemporal patterns of gene expression modify cellular behaviours to generate such deformations remain to be established. We use the Snapdragon flower as a model system to address this problem. Combining cellular analysis with tissue-level modelling, we show that an orthogonal pattern of growth orientations plays a key role in generating out-of-plane deformations. This growth pattern is most likely oriented by a polarity field, highlighted by PIN1 protein localisation, and is modulated by dorsoventral gene activity. The orthogonal growth pattern interacts with other patterns of differential growth to create tissue conflicts that shape the flower. Similar shape changes can be generated by contraction as well as growth, suggesting tissue conflict resolution provides a flexible morphogenetic mechanism for generating shape diversity in plants and animals.

KEYWORDS:

Antirrhinum majus; PIN1 polarity; developmental biology; morphogenesis; orthognal cell files; out-of-plane deformations; plant biology; stem cells; tissue conflict resolution

PMID:
28166865
PMCID:
PMC5295819
DOI:
10.7554/eLife.20156
[Indexed for MEDLINE]
Free PMC Article

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