Format

Send to

Choose Destination
Tissue Eng Part B Rev. 2017 Aug;23(4):347-361. doi: 10.1089/ten.TEB.2016.0462. Epub 2017 Mar 10.

Biomaterial-Guided Gene Delivery for Musculoskeletal Tissue Repair.

Author information

1
Department of Biomedical Engineering, University of California , Davis, Davis, California.

Abstract

Gene therapy is a promising strategy for musculoskeletal tissue repair and regeneration where local and sustained expression of proteins and/or therapeutic nucleic acids can be achieved. However, the musculoskeletal tissues present unique engineering and biological challenges as recipients of genetic vectors. Targeting specific cell populations, regulating expression in vivo, and overcoming the harsh environment of damaged tissue accompany the general concerns of safety and efficacy common to all applications of gene therapy. In this review, we will first summarize these challenges and then discuss how biomaterial carriers for genetic vectors can address these issues. Second, we will review how limitations specific to given vectors further motivate the utility of biomaterial carriers. Finally, we will discuss how these concepts have been combined with tissue engineering strategies and approaches to improve the delivery of these vectors for musculoskeletal tissue regeneration.

KEYWORDS:

biomaterials; controlled release; gene therapy; musculoskeletal

PMID:
28166711
PMCID:
PMC5749599
DOI:
10.1089/ten.TEB.2016.0462
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center