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IEEE/ACM Trans Comput Biol Bioinform. 2017 Jan 31. doi: 10.1109/TCBB.2017.2661761. [Epub ahead of print]

The SCJ Small Parsimony Problem for Weighted Gene Adjacencies.

Abstract

Reconstructing ancestral gene orders in a given phylogeny is a classical problem in comparative genomics. Most existing methods compare conserved features in extant genomes in the phylogeny to define potential ancestral gene adjacencies, and either try to reconstruct all ancestral genomes under a global evolutionary parsimony criterion, or, focusing on a single ancestral genome, use a scaffolding approach to select a subset of ancestral gene adjacencies, generally aiming at reducing the fragmentation of the reconstructed ancestral genome.

PMID:
28166504
DOI:
10.1109/TCBB.2017.2661761

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