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Biology (Basel). 2017 Feb 3;6(1). pii: E8. doi: 10.3390/biology6010008.

Metaphase Spindle Assembly.

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Laboratory of Chemistry and Cell Biology, the Rockefeller University, New York, NY 10065, USA.


A microtubule-based bipolar spindle is required for error-free chromosome segregation during cell division. In this review I discuss the molecular mechanisms required for the assembly of this dynamic micrometer-scale structure in animal cells.


cell division; chromosome; dynein; kinesin; metaphase; microtubules; mitosis

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