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J Appl Toxicol. 2017 Nov;37(11):1268-1285. doi: 10.1002/jat.3437. Epub 2017 Feb 6.

Preclinical safety assessments of nano-sized constructs on cardiovascular system toxicity: A case for telemetry.

Author information

1
Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
2
Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
3
Institute of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Republic of Serbia.
4
Polymer Therapeutics Lab, Centro de Investigación Príncipe Felipe, Av. Eduardo Primo Yúfera 3, E-46012, Valencia, Spain.
5
Department of Physiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Abstract

While nano-sized construct (NSC) use in medicine has grown significantly in recent years, reported unwanted side effects have raised safety concerns. However, the toxicity of NSCs to the cardiovascular system (CVS) and the relative merits of the associated evaluation methods have not been thoroughly studied. This review discusses the toxicological profiles of selected NSCs and provides an overview of the assessment methods, including in silico, in vitro, ex vivo and in vivo models and how they are related to CVS toxicity. We conclude the review by outlining the merits of telemetry coupled with spectral analysis, baroreceptor reflex sensitivity analysis and echocardiography as an appropriate integrated strategy for the assessment of the acute and chronic impact of NSCs on the CVS.

KEYWORDS:

Nanotoxicity; biocompatibility; cardiovascular toxicity assessment; nanomaterials; telemetry

PMID:
28165137
DOI:
10.1002/jat.3437
[Indexed for MEDLINE]

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