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Pharm Biol. 2017 Dec;55(1):974-979. doi: 10.1080/13880209.2017.1285323.

Regulatory/modulatory effect of prune essence concentrate on intestinal function and blood lipids.

Author information

1
a Department of Chinese Medicine , Taichung Hospital, Ministry of Health and Well-being , Taichung , Taiwan , ROC.
2
b School of Nutrition , Chung Shan Medical University , Taichung City , Taiwan , ROC.
3
c Department of Neurology , Chung Shan Medical University , Taichung City , Taiwan , ROC.
4
d School of Health Diet and Industry Management , Chung Shan Medical University , Taichung City , Taiwan , ROC.
5
e ITMO University , Saint-Peterburg , Russia.

Abstract

CONTEXT:

Prunus domestica Linn (Rosaceae) has been considered a functional food, owing to its various pharmacological activities, including antioxidant, anti-inflammatory, antidiabetic and anticancer.

OBJECTIVE:

This placebo-controlled, randomized study was framed to check the beneficial activity of prune essence concentrates (PEC) in corroboration with intestinal function and lipid profile in mildly hypercholesterolemic subjects.

MATERIALS AND METHODS:

Sixty healthy mild hypercholesterolemic subjects were randomly chosen and segregated into three groups as placebo (consume 50 mL of simulated prune drink), PEC I (consume 50 mL of PEC/day) and PEC II (consume 100 mL of PEC/day) for 4 weeks with 2 weeks of follow-up without PEC consumption.

RESULTS:

Intake of PEC (I and II) for 4 weeks substantially ameliorated (p < 0.05) the colony number of Bifidobacterium spp. (1.18- and 1.19-fold) and Lactobacillus spp. (1.07- and 1.16-fold), but markedly lowered (p < 0.05) the colony number of Clostridium perfringens (5.97 and 8.35%) and Escherichia coli (6.25 and 9.38%). Meanwhile, the total cholesterol (TC; 5.90 and 6.99%) levels and LDL-c (6.68 and 6.53%) were significantly reduced (p < 0.05), but no change in other lipid parameters. Whereas, the antioxidant capacity was also concomitantly elevated (p < 0.05) upon administration with PEC.

DISCUSSION AND CONCLUSION:

Overall, the results suggest that the use of PEC may positively regulate the intestinal microflora and thereby effectively lower the TC levels and thus act as a hypocholesterolemic agent.

KEYWORDS:

Hypercholesterolemic; antioxidant capacity; intestinal microflora; lipid profile

PMID:
28164731
PMCID:
PMC6130511
DOI:
10.1080/13880209.2017.1285323
[Indexed for MEDLINE]
Free PMC Article

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