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Clin Lab. 2016 Sep 1;62(9):1683-1687. doi: 10.7754/Clin.Lab.2016.160125.

Evaluation of Pleural Fluid Lactate for Diagnosis and Management of Parapneumonic Pleural Effusion.

Abstract

BACKGROUND:

The aim was to measure the accuracy of pleural fluid lactate concentration for diagnosis of parapneumonic pleural effusion (PPE) and to discriminate between uncomplicated (UPPE) and complicated PPE (CPPE).

METHODS:

Pleural fluid lactate was measured in patients with pleural effusion. Patients were classified into two groups according to the etiology of pleural effusion: PPE and NOT PPE.

RESULTS:

We studied 173 patients. Thirty patients were PPE (10 UPPE and 20 CPPE) and 143 were NOT PPE. The AUC value was 0.831 (p < 0.0001) and the optimal cutoff value was 5.6 mmol/L exhibiting 70% sensitivity and 90.9% specificity for diagnosis of PPE. Also, pleural fluid lactate could be used to discriminate between UPPE and CPPE, the AUC value was 0.740 (p = 0.0089) and the optimal cutoff value was 10.2 mmol/L, exhibiting 45% sensitivity and 90% specificity.

CONCLUSIONS:

Pleural fluid lactate has a high accuracy for diagnosis and management of PPE.

PMID:
28164581
DOI:
10.7754/Clin.Lab.2016.160125
[Indexed for MEDLINE]

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