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Fitoterapia. 2017 Mar;117:133-137. doi: 10.1016/j.fitote.2017.01.016. Epub 2017 Feb 3.

Flavonoids from the roots of Artocarpus heterophyllus.

Author information

1
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
2
Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
3
the People's Hospital of Yingshang, Yingshang 236200, China.
4
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA.
5
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA. Electronic address: firmblue@163.com.

Abstract

Four new flavonoids, artoheteroids A-D (1-4), together with six known ones (5-10), were isolated from the roots of Artocarpus heterophyllus. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR, UV, IR, CD, and HR-ESI-MS. All isolated compounds were screened for their inhibitory abilities against cathepsin K (CatK). Among them, compounds 1-2, 4-6, and 10 were found to have suppression capabilities against CatK with IC50 values ranging from 1.4 to 93.9μM.

KEYWORDS:

Artocarpus heterophyllus; Cathepsin K; Isoprenylated flavonoids; Structure elucidation

PMID:
28163073
DOI:
10.1016/j.fitote.2017.01.016
[Indexed for MEDLINE]

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